In the past decades, marine bioluminescent systems have been used increasingly by biologists and biochemists as tools for a large number of investigations such as protein-protein interactions, in cellulo or in vivo protein localisation using microscopy as well as high-throughput screenings.

We have developed in the laboratory an original and robust synthetic access for marine luciferins analogues and we have prepared more than one hundred previously unreported luciferins. Among them, some exhibit a bioluminescent signal up to 2.5 times brighter than the best luciferin available on the market, such improvements allowing a significant sensitivity improvements for techniques using these systems.

Depending on the state of advancement of our patent aplication process, these new luciferins will be disclosed along with some illustrations of their uses.